Two simple, sensitive, accurate and precise spectrophotometric methods (method A and method B) have been developed and validated for the determination of ofloxacin hydrochloride. The first method involved reduction of vanadium (V) to vanadium (IV) and development of greenish-blue colour which shows maximum absorption at 752nm. In the second method, ferric ions directly enters the active carboxylic acid and adjacent keto group in 3- and 4- position respectively and orange-red coloured complex is developed. The absorption maxima was found to be 420nm. The linearity range was found to be in concentration range 5-25�µg/ml for both the methods. The correlation coefficient was found to be 0.9994 and 0.9996 for method A and method B respectively. The regression equation was found to be y=0.056x.0021 and y= 0.0317x-0.0015 for method A and method B respectively. These methods were validated according to USP and ICH guidelines.
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